Tranexamic Acid (TXA) Infographic-Tranexamic Acid (TXA) Infographic

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Tranexamic Acid (TXA) is an anti-fibrinolytic drug that can help reduce mortality in adult trauma patients experiencing acute hemorrhaging if administered within three hours of injury. It is a synthetic equivalent of the amino acid lysine. However, there are certain contraindications and adverse effects associated with TXA. It should not be given to individuals with acquired defective color vision, hypersensitivity to TXA or its ingredients, or a known history of renal failure. Anaphylaxis is also a contraindication for use. Adverse effects may include thrombosis, nausea, vomiting, diarrhea, blurred vision, changes in color vision, and hypotension with a rapid infusion rate. <br /><br />General guidelines for the use of TXA in bleeding adult trauma patients are based on the CRASH-3 study. These guidelines specify that TXA should be administered within three hours of the time of injury in cases of severe hemorrhagic shock with a systolic blood pressure below 90 mmHg, a heart rate above 110 beats per minute, multi-system trauma with evidence of active hemorrhage, major pelvic fractures with evidence of active hemorrhage, solid organ injuries with evidence of active hemorrhage, traumatic amputations, or if there is a history of intravascular clotting or thromboembolism. <br /><br />The administration of TXA involves a loading dose bolus followed by an intravenous infusion. The loading dose bolus is typically 1 gram of TXA given over 10 minutes, followed by an intravenous infusion of 1 gram of TXA administered over 8 hours. The infusion is typically given with either 100 ml or 250 ml of normal saline. <br /><br />It's important to note that this information sheet is provided for informational purposes only and the Emergency Nurses Association (ENA) is not providing medical advice. It is always essential to consult with a medical practitioner or healthcare provider for guidance based on the specific clinical circumstances of a patient.

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TXA anti-fibrinolytic

TXA mortality

TXA trauma

TXA hemorrhage

TXA BP

Keywords

Tranexamic Acid

TXA

anti-fibrinolytic drug

mortality reduction

acute hemorrhaging

lysine

contraindications

adverse effects

CRASH-3 study

bleeding adult trauma patients